Bisphenol A (BPA) Puberty and Fat Tissue

An Assessment of Bisphenol A (BPA) during Pubertal Development: Relationship to Markers of Adiposity
Fertility and Sterility
Volume 95, Issue 4, Supplement , Page S28, 15 March 2011
M. Baker, I. Hernandez, F. Stanczyk, C. Azen, Y.-H. Hsu, D. Spruijt-Metz.

Background:
Bisphenol A (BPA) is an endocrine disruptor found in epoxy resins, used to coat the lining of metal food and beverage cans, as well as polycarbonate plastics. BPA has been shown to have estrogen receptor agonist activity, and potentially obesity-promoting activity. This is of key interest in young girls beginning the pubertal transition.

Objective(s):
To examine the relationship between BPA and pubertal stage, as well as physical and biochemical markers of adiposity.

Materials and Methods:
Prospective cohort analysis of 74 subjects, n=53 Latino and n=21 African-American girls, ages 8-11. Mean age was 9.8 yrs (SD 0.9yrs). Body mass index (BMI) and age- and gender-specific BMI percentile was calculated based on CDC growth charts. Percent body fat was determined by air displacement plethysmography. Visfatin, a marker of visceral fat, and BPA were determined by highly sensitive and specific ELISA.

Result(s):
Mean BPA levels were 0.36 ng/mL for Tanner stage 1 and 0.41 ng/mL for Tanner stage 2 subjects (p=0.76) at the time of enrollment. BPA was not correlated with BMI (r= -0.04, p=0.71), nor percent body fat (r= -0.01, p=0.95). There was a marginal positive correlation between BPA and visfatin levels (r=0.29, p=0.07).

Conclusion(S):
BPA levels did not differ in subjects at Tanner stage 1 or 2. Also no statistically significant correlations were found between BPA levels and BMI or percent body fat. Although the relationship between BPA and visfatin was not statistically significant, there may be a positive correlation between BPA and visfatin levels, an important adipocytokine seen in obesity.

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